Application

Rabbit Anti-MyCN antibody can be used for western blot applications at a concentration of 2.5µg/ml.

Biochem/physiol Actions

MYCN is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. It is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

MyCN is a basic helix-loop-helix protein that has been implicated neuroblastomas. Studies have linked childhood neuroblastomas with MyCN amplifications to caspase 8 supression.Rabbit Anti-MyCN antibody recognizes rat, canine, mouse, and human MyCN.

Immunogen

Synthetic peptide directed towards the C terminal region of human MYCN

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Sequence

Synthetic peptide located within the following region: EDAPPQKKIKSEASPRPLKSVIPPKAKSLSPRNSDSEDSERRRNHNILER