Application

Rabbit Anti-KCNN3 antibody is suitable for western blot assays at 2 µg/ml.

Biochem/physiol Actions

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. KCNN3, a member of the KCNN family of potassium channel genes, encodes a protein that is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

KCNN3 (SK3) codes for a voltage-independent, calcium-activated channel integral membrane protein. It may be involved in the modulation of neuronal excitability. KCNN3 has been linked to anorexia nervosa risk and atrial fibrillation.Rabbit Anti-KCNN3 antibody recognizes canine, human, mouse, rat, pig, and bovine KCNN3.

Immunogen

Synthetic peptide directed towards the C terminal region of human KCNN3

Physical form

 Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Sequence

Synthetic peptide located within the following region: ITELNDRSEDLEKQIGSLESKLEHLTASFNSLPLLIADTLRQQQQQLLSA