Anti-HDAC1

Application

Anti-HDAC1 polyclonal antibody is used to tag histone deacetylase 1 protein for detection and quantitation by Western blotting and in plasma by immunohistochemical (IHC) techniques. It is used as a probe to determine the roles of histone deacetylase 1 in a variety of gene activation cascades and cellular processes.

Biochem/physiol Actions

Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. HDAC1 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. HDAC1 also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, HDAC1 deacetylates p53 and modulates its effect on cell growth and apoptosis.Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Histone deacetylase 1 (HDAC1) is involved in the regulation of eukaryotic gene expression. HDAC1 is involved in the regulation of critical cell processes such as cell proliferation, differentiation and apoptosis. HDAC1 in association with other gene regulatory proteins regulates a wide range of specific gene cascades. For example HDAC1 is a regulator of retrotransposon expression in mouse embryonic stem cells. HDAC1 is the target of various histone deacetylase inhibitor under development as potential cancer therapeutic agent.

Immunogen

Synthetic peptide directed towards the C terminal region of human HDAC1

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Sequence

Synthetic peptide located within the following region: SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKP

Specificity

Anti-HDAC1 polyclonal antibody reacts with canine, human, mouse, rat, and bovine histone deacetylase 1 proteins.