Application

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

Biochem/physiol Actions

Cell adhesion molecule-related, downregulated by oncogenes (CDON) acts as a tumor suppressor gene in neuroblastomas. It acts as a high potential therapeutic target for PCa (prostate cancer). CDON functions as a receptor in SHH (sonic hedgehog) signaling pathway involved in neural crest cell fate during embryonic development. It is also known to activate apoptotic process in the absence of SHH pathway. CDO protein enhances myocardium formation of pluripotent stem cells.Nonsense mutation of CDON gene involved in SHH signaling will lead to congenital defect called as holoprosencephaly (HPE).CDO associates with co-receptor BOC (brother of CDO[cell adhesion molecule, down-regulated by oncogenes)] by mutually linking their internal domains and ectodomains. This complex is involved in the regulation of myogenic differentiation.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.Every Prestige Antibody is tested in the following ways: IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues. Protein array of 364 human recombinant protein fragments.

General description

Cell adhesion molecule-related, downregulated by oncogenes (CDON) gene is mapped to human chromosome 11q23–24. The CDO protein encoded by this gene is a known cell surface receptor of the immunoglobulin superfamily This cell surface protein consists of five Ig repeats and three fibronectin type III (FNIII) repeats in its extracellular region, a transmembrane domain and a peculiar 270 amino acid intracellular region.

Immunogen

Cell adhesion molecule-related/down-regulated by oncogenes precursor recombinant protein epitope signature tag (PrEST)

Legal Information

Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC

Linkage

Corresponding Antigen APREST71633.

Physical form

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide