Application

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

Biochem/physiol Actions

ATRN (attractin) functions as a dipeptidyl peptidase IV, and promotes the initial clustering of immune cells. It also controls the activity of chemotactic activity of chemokines. In humans, it is expressed in both sperm plasma and sperm extract, and is thought to be involved in male reproduction and acts as an active substance.

Features and Benefits

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.Every Prestige Antibody is tested in the following ways: IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues. Protein array of 364 human recombinant protein fragments.

General description

ATRN (attractin) is a human homolog of the murine mahogany product, which exists in both membrane and secreted forms. It is expressed and secreted by activated T-cells. This gene is localized to human chromosome 20p13, and consists of 25 exons. It is a serum glycoprotein with a molecular weight of 175kDa. The membrane protein is hematopoietic tissue-specific and has a molecular weight of 134kDa. It contains a predicted serine protease catalytic domain, four EGF (epidermal growth factor)-like motifs, a CUB (complement C1r/C1s, Uegf, Bmp1) domain and a C-type lectin domain. It also contains a ligand-binding region homologous to the ligand-binding region of γ-cytokine chain.

Immunogen

Attractin precursor recombinant protein epitope signature tag (PrEST)

Legal Information

Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC

Linkage

Corresponding Antigen APREST71684.

Physical form

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide