Application

All Prestige Antibodies^®Powered by Atlas Antibodies is developed and validated by the Human Protein Atlas (HPA) project . Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

Anti-AOC1 antibody produced in rabbit has been used in western blotting.

Biochem/physiol Actions

AOC1 (amine oxidase, copper containing 1) catalyzes the oxidative deamination of primary amines to the corresponding aldehydes. It breaks down polyamines and histamine. Mutation in the gene causes histamine intolerance due to excess of histamine. Decreased expression of AOC1 might be associated with the risk of migraine, especially in women of Caucasian Spanish origin.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.Every Prestige Antibody is tested in the following ways: IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues. Protein array of 364 human recombinant protein fragments.

General description

AOC1 (amine oxidase, copper containing 1) is mapped to human chromosome 7q36.1. AOC1 codes for a histamine-degrading enzyme diamine oxidase. The encoded protein is highly expressed in mature upper villus cells of the intestinal mucosa.

Immunogen

amiloride binding protein 1 (amine oxidase (copper-containing)) recombinant protein epitope signature tag (PrEST)

Legal Information

Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC

Linkage

Corresponding Antigen APREST77696.

Physical form

Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.