Biochem/physiol Actions

Anle138b, an oligomer modulator, inhibits neuronal degeneration. It rescues neurons from the aggregationeffects of α-synuclein.

Anle138b is a fluorescent inhibitor of α-synuclein and prion-protein (PrPSc) aggregation that reduces the progression of prion and Parkinson′s disease in animal models. Anle138b extends the survival of mice infected with prions. Anle138b strongly inhibits BSE-derived and human prions. The fluorescence strongly increases upon binding with α-synuclein fibrils. Apparently, Anie138b binds to hydrophobic pockets in the fibrils.

Packaging

5, 25 mg in glass bottle