Biochem/physiol Actions

Primary TargetNa⁺, K⁺-ATPase activity

Product does not compete with ATP.

Target IC₅₀: 120 µM against Na⁺, K⁺-ATPase activity

General description

4-Hydroxynonenal, CAS 75899-68-2, is a major aldehyde product formed by peroxidation of Ω-6-unsaturated fatty acids that is regarded as a specific marker of lipid peroxidation.

A major aldehydic product formed by peroxidation of Ω-6-unsaturated fatty acids that is regarded as a specific marker of lipid peroxidation. Inhibits proliferation and induces differentiation of HL-60 human leukemic cells. Also induces cell death in murine alveolar macrophages. An inhibitor of State 3 respiration at micromolar levels that causes a transient increase in cytosolic Ca²⁺. Irreversibly inhibits Na⁺-K⁺-ATPase activity (IC₅₀ = 120 µM).

A major aldehyde product formed by peroxidation of Ω-6-unsaturated fatty acids that is regarded as a specific marker of lipid peroxidation. Inhibits proliferation and induces differentiation of HL-60 human leukemic cells. Also induces cell death in murine alveolar macrophages and in PC12 cells. An inhibitor of state 3 respiration at micromolar levels. Causes a transient increase in cytosolic Ca²⁺ and irreversibly inhibits Na⁺, K⁺-ATPase activity (IC₅₀ = 120 µM). Acts as a reversible inhibitor of c-Jun N-terminal kinase (JNK).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Soh, Y., et al. 2000. Mol. Pharmacol.58, 535.Carini, R., et al. 1996. Biochem. Biophys. Res. Commun.218, 772.Li, L., et al. 1996. Toxicol.Appl. Pharmacol.139, 135.Siems, W.G., et al. 1996. Free Radic. Res.20, 215.Ullrich, O., et al. 1996. Free Radic. Res.24, 421.van Kuijk, F.J., et al. 1995. Anal. Biochem. 224, 420.Esterbauer, H., et al. 1991. Free Radic. Biol. Med.11, 81.

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Packaging

1 mg in Glass bottle

Physical form

Supplied at 10 mg/ml in ethanol

Reconstitution

Following initial thaw, aliquot and freeze (-70°C).

Warning

Toxicity: Flammable (J)