Biochem/physiol Actions

Target K_i: 0.57, 7.3, 0.37, 0.72 and 0.55 nM at human M1, M2, M3, M4, and M5 receptors respectively

Primary TargetMuscarinic Receptors

General description

An antagonist selective for mAChRs (K_i = 0.57, 7.3, 0.37, 0.72 and 0.55 nM at human M1, M2, M3, M4, and M5 receptors respectively). Used frequently in investigating the functional roles of M1 and M3 receptors in both central and peripheral nervous systems.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Kruse, C., et al., 2012. Nature.482, 552.Moriya, H., et al., 1999. Life Sci.64, 2351.Ehlert, J., 1996. Life Sci.58, 1971.

Packaging

25 mg in Glass bottle

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)