Application

1-O-Acyl-Ceramide is suitable for use as a lipid standard inhigh performance thin layer chromatography (HPTLC)in mass and nuclear magnetic resonance spectroscopy for the quantification of lipids isolated from vernix caseosa skin creamin liquid chromatography-tandem mass spectrometry for the quantification of 1-O-Acyl ceramides from liver samples

Biochem/physiol Actions

1-O-Acyl-Ceramide functions in maintaining water barrier homeostasis. Deficiency of the glucosylceramide synthase enzyme leads to the accumulation of O-acylceramides. Treatment of human monoclonal antibody, REMD 2.59 leads to the accumulation of 1-O-acyl-ceramides in soleus muscle and depletion in liver.

General description

1-O-Acyl-Ceramide is an epidermal ceramide present in mouse and human epidermis. It comprises long chain fatty acids in 1-O-position and is synthesized in the endoplasmic reticulum-related sites.

Packaging

5 mL Amber Glass Screw Cap Vial (860526P-5mg)