Application

1-deoxysphingosine may be used for the complex preparation with bovine serum albumin for cytotoxicity testing of MN9D dopaminergic neuroblastoma cell line and dorsal root ganglion neurons cultures. It may also be used as a standard for quantification of spingolipids from human plasma samples by liquid chromatography electrospray ionization tandem mass spectrometry (LC−ESI−MS/MS).

Biochem/physiol Actions

1-deoxysphingosine levels are elevated in lymphoblasts in hereditary sensory neuropathy type 1 (HSAN1) disorder.

General description

1-deoxysphingosine (1-deoxySO) has a (4E) double bond in its structure and is synthesized by the catabolism of 1-deoxyceramide in the presence of ceramidase enzyme. It is an unsaturated deoxy-sphingoid base.

Packaging

5 mL Amber Glass Screw Cap Vial (860470P-1mg)

5 mL Amber Glass Screw Cap Vial (860470P-10mg)