General description
A potent allosteric antagonist of vertebrate GABAA receptors. Blocks GABAA-induced chloride currents in cultured neurons (IC50 = 740 nM). Shown to increase blood pressure in spontaneously hypertensive rats and cause convulsion in experimental animals. Also, increases the amplitude of spontaneous colonic contractions.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
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Ueno, S., et al. 1997. J. Neurosci.17, 625.Uchida, I., et al. 1996. Eur. J. Pharmacol.307, 89. Minocha, A., and Galligan, J.J. 1993. Eur. J. Pharmacol.230, 187.Robert K.A., et al. 1993. Cardiovasc. Pharmacol.21, 156.
Packaging
50 mg in Glass bottle
Warning
Toxicity: Toxic (F)
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