(S)-(-)-Propranolol hydrochloride, >=98% (TLC), powder

Code: P8688-100MG D2-231

Application

(S)-(−)-Propranolol hydrochloride has been used:as a non-selective β-blocker propranolol to inhibit the actions of epinephrine in miceas a β1- and β2-aad...


 Read more

Your Price
€114.78 100MG
€141.18 inc. VAT
REQUEST

Application

(S)-(−)-Propranolol hydrochloride has been used:as a non-selective β-blocker propranolol to inhibit the actions of epinephrine in miceas a β1- and β2-aadrenergic receptor blocker in ratas a medium supplement to investigate its effect on adipogenesis in hemangioma-derived stem cells (HemSC)

Biochem/physiol Actions

Active β-adrenoceptor blocking enantiomer, as measured by inhibition of isoprenaline-induced tachycardia; Propranolol is also non-specific 5-HT1A, 5-HT1B and 5-HT1C serotonin receptor antagonist. The stereoselective association of mianserin and propranolol with the 5HT1A, 5HT1B and 5HT1C sites may prove useful in the characterization of these sites

(S)-(−)-Propranolol hydrochloride is biologically active enantiomer. It acts as β1 receptor antagonist in thalamocortical neurons. (S)-(−)-Propranolol hydrochloride elicits its inhibitory function on the β1 adrenoceptor in trigeminovascular pain pathway and serves as a preventive medicine in migraine.

Features and Benefits

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Packaging

100, 500 mg in glass bottle

assay≥98% (TLC)
formpowder
Gene Informationhuman ... ADRB1(153), ADRB2(154), ADRB3(155), HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355)
InChI keyZMRUPTIKESYGQW-UQKRIMTDSA-N
InChI1S/C16H21NO2.ClH/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16;/h3-9,12,14,17-18H,10-11H2,1-2H3;1H/t14-;/m0./s1
mp193-195 °C (lit.)
optical activity[α]25/D −25.5°, c = 1.0 in ethanol(lit.)
originatorAstraZeneca
Quality Level200
SMILES stringCl[H].CC(C)NC[C@H](O)COc1cccc2ccccc12
solubilityDMSO: ﹤14.5 mg/mL, ethanol: 10 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 8.0 mg/mL, H2O: 50 mg/mL (With heat. Aqueous solutions are most stable at pH 3.0 and decompose rapidly at basic pH. Decomposition is accompanied by discoloration of the solution.)
storage temp.2-8°C
Cas Number4199-10-4
This product has met the following criteria to qualify for the following awards:



PROCEED TO CHECKOUT

HAVE AN ACCOUNT? LOGIN
GUEST CHECKOUT

Proceed as a guest. You will have the option to register to access exclusive pricing and stock availability features after checkout.