Hyaluronic acid sodium salt from bovine vitreous humor,

Application

Hyaluronic acid sodium salt from bovine vitreous humor has been used:as a component for the generation of artificial synovial fluidto investigate its role in inducing oxidative stress and interleukin 8(IL-8) production in human nasal RPMI 2650 cellsto test its effect on B cell proliferationas a substrate in neuraminidase assay of morbilliviruses virus

Biochem/physiol Actions

High molecular mass polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine which forms the core of complex proteoglycan aggregates found in extracellular matrix.

Hyaluronic acid (HA) is abundantly present in the bovine vitreous humor. It corresponds to a molecular weight of 69293.9Da and has an isoelectric pH of 5.82. Bovine HA has high levels of endotoxins and it polydisperse with DNA and RNA contaminants. The enzyme HA synthases at the plasma membrane (HASs) aids in the synthesis of circulatory HA. HA is implicated in many physiological processes including inflammation, immune regulation, adhesion, embryo development and tumor progression.

Packaging

10, 50 mg in poly bottle