Mouse monoclonal anti-cellular*fibronect in, clone f

Code: F6140-.2ML D2-231

Application

Monoclonal Anti-Fibronectin, Cellular antibody produced in mouse has been used in:immunoblot immunofluorescent microscopyimmunocytochemistry

Biochem...


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Application

Monoclonal Anti-Fibronectin, Cellular antibody produced in mouse has been used in:immunoblot immunofluorescent microscopyimmunocytochemistry

Biochem/physiol Actions

Fibronectin may enhance cell adhesion and spreading and affect the routes of cell migration both in vivo and in culture. It has been shown that upon malignant transformation many cells lose their surface bound fibronectin.

Fibronectin is a soluble plasma protein that regulates tissue repair and thrombus formation. Insoluble fibronectin is expressed in basement membranes and connective tissue matrix and mainly modulates cell adhesion and migration. Alterations in fibronectin have been associated with microvascular thrombosis, disseminated intravascular coagulation, and atherosclerosis .

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Monoclonal Anti-Cellular Fibronectin (mouse IgM isotype) is derived from the hybridoma produced the fusion of mouse myeloma cells and splenocytes from immunized mice. Fibronectin is an extracellular matrix protein composed of two nearly identical disulfide-bound polypeptides with typical molecular weights of 220-240 kDa. Cellular fibronectin is structurally and antigenically similar to cold insoluble globulin from plasma and polyclonal antibodies to either form usually cross-react. The protein contains several functionally and structurally distinct domains, which may bind to cell surfaces, collagen, heparin, etc.

Immunogen

fibronectin antigen released in culture by a human breast cancer cell line

Specificity

The antibody labels cellular fibronectin in the pericellular matrix of chick embryo and mouse and human fibroblasts grown in tissue culture. It may be used for immunoaffinity purification of cellular fibronectin.

antibody formascites fluid
antibody product typeprimary antibodies
biological sourcemouse
cloneFN-3E2, monoclonal
conjugateunconjugated
contains15 mM sodium azide
Gene Informationhuman ... FN1(2335)mouse ... Fn1(14268)
isotypeIgM
mol wtantigen 240 kDa
Quality Level200
shipped indry ice
species reactivitychicken, human, mouse
storage temp.−20°C
technique(s)western blot: suitable, immunoprecipitation (IP): suitable, indirect immunofluorescence: 1:400 using cultured chicken fibroblasts, immunohistochemistry (frozen sections): suitable, radioimmunoassay: suitable, immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
UniProt accession no.P02751
Code
Description
Unit Size
List Price
Qty
F6140-100UL
Unit:100UL
List Price: €579.00
Source:List Price
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